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. 2018 Aug 6;14(11):1445–1456. doi: 10.7150/ijbs.26335

Figure 8.

Figure 8

Schematic model of miR-485-3p in osteosarcoma cells. (A) The working model of miR-485-3p in normal cells. In normal cells, the CpG methylation level in the miR-485-3p promoter region is very low, which cannot effectively inhibit the expression of miR-485-3p, resulting in the upregulation of miR-485-3p, downregulation of CtBP1 expression, and upregulation of CtBP1 downstream targets. (B) The working model of miR-485-3p in osteosarcoma cells. In osteosarcoma cells, the CpG methylation level in the miR-485-3p promoter region is very high, which significantly inhibits the expression of miR-485-3p, resulting in the downregulation of miR-485-3p, upregulation of CtBP1 expression, and downregulation of CtBP1 downstream targets, which eventually leads to carcinogenesis.