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Model of two-phase chromatin remodeling at sites of DNA damage. DNA damage promotes the recruitment of PARP1 where it is activated. Activated PARP1 will PARylate proteins at the site of damage, including itself, and promote the recruitment of the chromatin remodeler, Alc1. Alc1 remodeling activity leads to chromatin relaxation in the vicinity of the DNA break. CHD3 and CHD4 bind to the relaxed chromatin and further remodel chromatin.
