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. 2018 Mar 29;46(12):6318–6329. doi: 10.1093/nar/gky233

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© The Author(s) 2018. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 7. — Edc1 and Edc3 coordinate to activate the Dcp1:Dcp2_ext complex. (A) Plot of k_obs versus Edc1 concentration for the catalytic core (orange), autoinhibited complex (cyan), or the autoinhibited complex (Dcp1:Dcp2_ext) saturated with Edc3 (purple). Error bars are population standard deviation, σ. (B) Bar graphs showing the K_1/2 Edc1 activation (apparent K_d) determined from the fits in panel A for Edc1 dependent activation with same colors as in A. Error bars are standard error. Differences in k_1/2 are significant except for Dcp1:Dcp2_core relative to Dcp1:Dcp2_ext:Edc3 as determined by unpaired t-test (see Supplementary Table S3).