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Biodistribution of Adnectins conjugated to [3H]-tubulysin analog in mice harboring Glypican-3-positive tumors derived from Hep3B cells. Whole body autoradiograph of a mouse sacrificed 5 h after administration of [3H]—A1H-tub (A) and [3H]—A-RGE-H-tub (B). Quantified radioactivity in selected tissues, 5 h (C) and 168 h (D) after the administration of [3H]—A1-H-tub (red bars) vs. [3H]—A-RGE-H-tub (black bars).
