Table 4.
Cerebral response to cardiac surgery
| Placebo (n = 15) | Methylprednisolone (n = 15) | Between group analysis, p value | |||
|---|---|---|---|---|---|
| Preoperative | Postoperative | Preoperative | Postoperative | ||
| CSF S-100B (μg/L)# | 0.94 (0.26) | 0.88 (0.42) | 0.94 (0.36) | 1.14 (0.54)* | 0.47 |
| CSF GFAP (ng/l) | 643 ± 387 | 683 ± 388 | 684 ± 412 | 763 ± 422 | 0.54 |
| CSF NSE (μg/L)# | 4.55 (2.2) | 4.82 (2.7) | 3.60 (3.9) | 6.15 (3.7) | 0.36 |
| CSF NFL (ng/L) | 990 ± 442 | 1031 ± 442 | 1125 ± 583 | 1120 ± 527 | 0.43 |
| CSF T-tau (ng/L)# | 295 (233) | 301 (269)* | 324 (111) | 288 (156) | 0.085 |
| CSF albumin (mg/L) | 286 ± 80 | 283 ± 89 | 238 ± 94 | 255 ± 100 | 0.28 |
| CSF/serum albumin ratio 95% CI |
6.42 ± 1.5 (5.5–7.3) |
8.0 ± 2.4** (6.7–9.3) |
5.56 ± 2.3 (4.4–6.8) |
7.20 ± 3.1** (5.5–8.9) |
0.98 |
| CSF TNF-α (ng/L)# | 0.15 (0) | 0.15 (0.08)** | 0.15 (0) | 0.15 (0.06)* | 0.905 |
| CSF IL-6 (ng/L) | 0.833 ± 0.23 | 6.69 ± 4.9*** | 1.01 ± 0.39 | 2.44 ± 1.5** | 0.001 |
| CSF IL-8 (ng/L)# | 40.0 (13) | 130 (93)*** | 46.0 (15) | 321 (275)*** | < 0.001 |
Values are mean ± SD, or median (IQR)#; not normally distributed data—non-parametric tests used. CSF cerebrospinal fluid, GFAP glial fibrillary acidic protein, IL-6 interleukin-6, IL-8 interleukin-8, NSE neuron-specific enolase, NFL neurofilament light chain protein, T-tau total tau, TNF-α tumor necrosis factor alpha. *p < 0.05, **p < 0.01, ***p < 0.001, within-group