Fig. 5.

Transplantations of MSCs or MSC-Exos increase the smooth muscle contents of the corpus cavernosum. a The expressions of SMA in the corpus cavernosum were detected at 4 weeks in each group. Original magnification, ×200 DAPI = 4′,6-diamidino-2-phenylindole. b Representative images of Masson trichrome staining of actin and collagen in each group. Smooth muscle and connective tissue in the corpus cavernosum are stained red and blue, respectively. Original magnification, ×200. c Representative images of western blots for SMA cavernosum in each group. d Data are presented as the relative density of SMA compared with that of β-actin. The density was determined semiquantitatively using ImageJ. Each bar depicts the means ± standard deviations from n = 8 animals per group. *p < 0.05 compared with the PBS vehicle group. e Effect of MSCs or MSC-Exos treatment on the ratio of smooth muscle to collagen in the corpus cavernosum. Bars denote the mean densitometry ratio between smooth muscle content and collagen content per field (± standard error of the mean). *p < 0.05 compared with the PBS vehicle group