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. 2018 Sep 26;16:262. doi: 10.1186/s12967-018-1635-z

Fig. 4.

Fig. 4

Molecular mechanisms of airway smooth muscle function changes in COPD. The ASM in patients with COPD can act as a producer of pro-and anti-inflammatory mediators (e.g. cytokines, chemokines, growth factors), to regulate the local immune environment and influence proliferation, migration, and apoptosis of other resident cells