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. 2018 Sep 27;19:136. doi: 10.1186/s13059-018-1514-1

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — DNAm and polygenic prediction of health and lifestyle factors. Proportion of phenotypic variance explained (R²) is plotted for eight traits: BMI; smoking; alcohol consumption (alcohol); education; total cholesterol (TC); HDL cholesterol (HDL); LDL with remnant cholesterol (LDL); and total:HDL cholesterol ratio (TC:HDL) based on each trait’s polygenic score (blue), DNA methylation-based score (green), and additive genetic + epigenetic score (orange)