Table 1.
Drug preparations and treatment details
| Drug | Supplier | Preparationa | PDX assayb | MiniPDX assayb |
|---|---|---|---|---|
| S-1 | Hengrui | 0.5% HPMC + 0.2% Tween 80 | 10 mg/kg, po, qd*5/w | 10 mg/kg, po, qd*5 |
| Docetaxel | DEMO | 5% Tween 80 + 5% Ethanol + 90% Saline | 20 mg/kg, ip, q4d | 20 mg/kg, ip, q4d*2 |
| Gemzar | Eli Lilly | Saline | 60 mg/kg, ip, q4d | 60 mg/kg, ip, q4d*2 |
| Oxaliplatin | Hengrui | 5% Glucose | 5 mg/kg, ip, biw | 5 mg/kg, ip, q4d*2 |
| Irinotecan | DEMO | 5% DMSO + 95% Saline | 40 mg/kg, ip, q4d | 50 mg/kg, ip, q4d*2 |
| Cisplatin | Hansoh | Saline | 5 mg/kg, ip, qw | 5 mg/kg, ip, q4d*2 |
| Epirubicin | Pfizer | Saline | 5 mg/kg, ip, qw | 5 mg/kg, ip, q4d*2 |
| Capecitabine | Adamas | 0.5% HPMC + 0.2% Tween 80 | 400 mg/kg, po, qd*14 | 400 mg/kg, po, qd*7 |
| 5-FU | Xudong-Haipu | Saline | 25 mg/kg, ip, qd*5/w | 25 mg/kg, ip, qd*5 |
| Erlotinib | Topscience | 0.5% HPMC + 0.2% Tween 80 | 50 mg/kg, po, qd | 50 mg/kg, po, qd*7 |
| Crizotinib | Aladdin | 0.5% HPMC + 0.2% Tween 80 | 50 mg/kg, po, qd | 50 mg/kg, po, qd*7 |
| AZD9291 | Topscience | 0.5% HPMC + 0.2% Tween 80 | 5 mg/kg, po, qd | 5 mg/kg, po, qd*7 |
po oral, ip intraperitoneal, qd once a day, biw twice a week, qw once a week, q4d once every 4 days
a Recipe of formulation
b Dose, dosing route, dosing frequency followed by, where indicated, dosing times and/or treatment duration