Table 4.

Adverse events of CAM for childhood atopic eczema in randomized controlled trials

Study ID	Total sample num	Sample num in intervention group	Sample num in control group	Adverse events cases	Intervention group	Control group	Treatment for adverse event
C. Gore 2011 [43]	208	137	71	T: 42/137 C: NR	green loose stools; increased vomiting; feed-refusal; colic	NR	24/137 (17.5%) participants stopped the study formula.
Chen YL 2015 [24]	116	58	58	T: 1/58 C: 2/58	1 for dizzy.	1 for dizzy; 1 for drowsy.	NR
Liu CH 2009 [20]	298	150	148	T: 0/150 C: 57/148	None	21 for facial flushing; 18 for dry skin; 8 for partial facial skin thinning; 10 for facial skin with mild pigmentation; Unclear for other hormonal dermatitis symptoms.	NR
Sergei V. Gerasimov 2010 [37]	96	48	48	T: 26/48 C: 24/48	11 for upper respiratory tract infections; 4 for lower respiratory tract infections; 7 for herpetic stomatitis; 3 for diarrhea; 6 for constipation; 5 for abdominal colic; 2 for burn and croup with severe adverse events.	10 for upper respiratory tract infections; 5 for lower respiratory tract infections; 5 for herpetic stomatitis; 2 for diarrhea; 6 for constipation; 4 for abdominal colic; 3for head injury, food poisoning with severe adverse events.	None was related to the medications under investigation.
Wu YQ 2014 [22]	148	74	74	T: 2/74 C: 5/74	2 for crying and mildly red skin lesions on the 2nd day.	5 for crying, irritability, and red skin lesions.	Without any treatment, to ease soon and symptoms disappearance.
Ye CQ 2017 [30]	96	48	48	T:3/48 C:14/48	1 for diarrhea; 2 for constipation.	6 for diarrhea; 8 for constipation.	NR
Zhang XN 2013 [32]	70	36	34	T: 1/36 C: 2/34	1 for mild skin irritation after using Velvetfeeling Lotion	2 forskin lesions reddening after using Butyl Flufenamate Ointment.	Without any treatment, to ease soon and symptoms disappearance.

T treatment group, C control group, NR not report