TABLE 3. Comparison of Q-SHIP Participants Who Did and Did Not Start Hydroxyurea.
There were no differences between those who did and did not start hydroxyurea according to previous hydroxyurea offer, participation in a group session or while hospitalized, or clinical variables including baseline hemoglobin and %HbF, ED visits, or intensive care unit admission.
| Started HU after Q-SHIP N=36 |
Did not start HU after Q-SHIP N=30 |
p-value | |
|---|---|---|---|
| Age, median years (IQR) | 7.5 (5.0, 15.3) | 9.3 (3.1, 16.3) | 0.94 |
| Reported previous HU offera | 22/35 (63%) | 14/30 (47%) | 0.19 |
| Group Q-SHIP session with other patient families | 20 (56%) | 15 (50%) | 0.66 |
| Attended Q-SHIP… …after only an ED visit …during a hospitalization …after a hospitalization |
13 (36%) 8 (22%) 15 (42%) |
10 (33%) 6 (20%) 14 (47%) |
0.81 0.83 0.68 |
| Days from ED or hospital discharge to Q-SHIP participation, median (IQR) | 5 (2, 20) | 8 (3, 28) | 0.59 |
| Baseline hemoglobin, mean g/dl (SD) | 8.3 (1.2) | 8.6 (1.0) | 0.29 |
| Baseline %HbF, mean % (SD)b | 15.0 (9.5) | 16.9 (9.3) | 0.43 |
| Number of ED visits or hospitalizations for pain or ACS in prior 2 years, median (IQR) | 3 (2, 5) | 2 (2, 4) | 0.29 |
| Prior PICU admission or transfer | 12 (33%) | 5 (17%) | 0.12 |
| Number of prior transfusions, median (IQR) | 2 (1, 5) | 1 (0, 4) | 0.12 |
a
n=65, one patient did not compete pre-session questionnaire;
b
n=63, three patients did not have baseline %HbF.