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. Author manuscript; available in PMC: 2018 Sep 27.
Published in final edited form as: Int J Neurodegener Dis. 2018 Feb 23;1(1):002. doi: 10.23937/IJND-2017/1710002

Figure 2. Localization of an amino-terminal fragment of apoE within Lewy bodies of the human PD brain (A–F).

Figure 2

Representation images from confocal immunofluorescence in two different PD cases utilizing antibodies nApoECFp17 (A and D), α-Syn (B and E), with the merged images shown in (C and F). Strong co-localization of the two antibodies was observed in Lewy bodies of the PD brain; (G): Quantification of the number of Lewy bodies doubled-labeled with nApoECFp17 and α-Syn indicated co-localization in 87.5% of the total number of Lewy bodies identified in the substantia nigra. Data depict the number of α-Syn-labeled Lewy bodies alone (blue bar) and the number of Lewy bodies labeled with both α-Syn and nApoECFp17 (orange bar) identified in substantia nigra PD sections by immunofluorescence microscopy (n = 3 different PD cases ± S.D.). All scale bars represent 5 µm. Asterisk denotes significant difference, p = 0.018.