Tabla 1.
Difusión y dosis de antibióticos en infecciones del SNC. Referencia [26], con permiso del autor
| ANTIBIÓTICO | DOSIS INTRAVENOSA (para adultos) | DOSIS INTRATECAL (dosis diaria en mg) | Concentración en LCR en relación con concentración sérica (%) |
|---|---|---|---|
| Amikacina | 5 mg/kg/8 h | 5-50 | 10 |
| Ampicilina | 2 g/4 h | -- | 10 |
| Anfotericina B | 1-3 mg/kg/día | 0,1-0,5mg/día | <10 |
| Aztreonam | 2 g/6-8 h | -- | 5-10 |
| Cefepima | 2 g/8h | -- | 20 |
| Cefotaxima | 2 g/4-6 h | -- | 20 |
| Ceftazidima | 2 g/6-8 h | -- | 10 |
| Ceftriaxona | 2 g/12 h | -- | 10 |
| Ciprofloxacino | 400 mg/ 8-12 h | -- | 40 |
| Cloranfenicol | 1-2 g/6 h | -- | 50-80 |
| Cloxacilina | 2 g/4 h | -- | <5 |
| Colistina | 1-2 mU/8 h | 10-20 | 5-25 |
| Cotrimoxazol | 320/1600 mg/6-8 h | -- | 30-50 |
| Etambutol | 12-25mg/kg/día | -- | 25 |
| Fosfomicina | 100-300 mg/kg/día | -- | 25 |
| Gentamicina | 5 mg/kg/24 h | 5 mg/día | 10 |
| Daptomicina | 6 mg/kg/día | 5-10 mg/3 días | <5 |
| Isoniazida | 5mg/kg/día | -- | 80 |
| Levofloxacino | 500 mg/12 h | -- | 80 |
| Linezolid | 600 mg/12 h | -- | 90 |
| Metronidazol | 500 mg/6-8 h | -- | 80 |
| Meropenem | 1-2 g/6-8 h | -- | 30 |
| Moxifloxacino | 400 mg/24 h | -- | 80 |
| Penicilina G | 4 mU/4 h | -- | 5-10 |
| Pirazinamida | 25-35 mg/kg/día | 90 | |
| Rifampicina | 600 mg/24 h | -- | 20 |
| Teicoplanina | 200 mg/12 h | 5-40 mg/día | <5 |
| Tobramicina | 5 mg/kg/8 h | 5-20 mg/día | 10 |
| Vancomicina | 10-25 mg/kg/8-12h | 5-20 mg/día | 20 |