Table 4: Non-conventional and Experimental Treatment of Diabetic Cardiomyopathy.

Superoxide dismutase	Transgenic mice with DM expressing cardiac specific superoxide dismutase have shown improvement in cardiac remodeling and left ventricle function[77]
Coenzyme Q10	Effectively targets reactive oxygen species in diabetic mice and prevented effectively diabetic cardiomyopathy[78]
Phosphoinositide 3-kinase	In transgenic mice prevented diabetes-induced cardiomyopathy[79]
Omega-3 (n-3) polyunsaturated fatty acids	Improved ejection fraction in a rat model of DM[80]
B-type natriuretic peptide	Chronic treatment at low doses improved the metabolic profile and prevented the development of myocardial dysfunction in obese diabetic mice[81]
p38 MAPK	Inhibition of p38 MAPK by SB203580 (a pharmacological inhibitor) prevented cardiac inflammation and attenuated left ventricular dysfunction in a mouse model of diabetic cardiomyopathy[82]

DM = diabetes mellitus; MAPK = mitogen-activated protein kinase.