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PCSK 9 enters the secretory pathway through the Golgi network. Circulating PCSK9 binds to LDL-R on cellular surface of hepatocytes. Bound LDL-P to LDL-R is internalised along with PCSK9. In the endosome, the bound PCSK9 targets LDL-R in the endosome for degradation, subsequently lowering LDL-R levels and increasing circulating LDL-P and LDL-C. LDL-R = LDL receptor; LDL-P = LDL particle.
