Table 2: Risk Factors for Statin Intolerance.
| Patient Characteristics | Co-morbidities | Genetics | Medications |
|---|---|---|---|
| Advanced age (>80 years) | Hypothyroidism | Polymorphisms of CYPD isoenzymes | Drug-drug interactions |
| Female sex | Chronic kidney disease | Polymorphisms in drug transporter genes | Antidepressant or antipsychotic use |
| Small body frame and frailty | Diabetes mellitus | Illicit drug use | |
| Asian ancestry (for rosuvastatin) | Multisystem disease | High dose statin use | |
| Grapefruit juice (>1 quart/day) | Alcoholism | ||
| Excessive physical activity | Major surgery | ||
| History of myopathy | Intercurrent infections | ||
| History of CK elevation | Muscle disease | ||
| Unexplained cramps | |||
| Family history of myopathy | |||
| Family history of statin-induced myopathy |
Adapted from Ahmad, 2014.[27]