Table 1: Clinical Criteria for the Diagnosis of Heterozygous Familial Hypercholesterolaemia from the Dutch Lipid Clinic Network.

Family history	Score
1. First-degree relative with premature coronary heart disease or 2. First-degree relative with LDL cholesterol >95th percentile by age and gender for country 3. First-degree relative with xanthoma and/or arcus cornealis or 4. Children <18 years with LDL cholesterol >95th percentile by age and gender for country	1 1 2 2
Clinical history
1. Premature coronary heart disease 2. Premature cerebral or peripheral vascular disease	2 1
Physical examination
1. Tendon xanthoma 2. Arcus cornealis <45 years	6 4
LDL cholesterol
1. >8.5 mmol/l 2. 6.5–8.4 mmol/l 3. 5.0–6.4 mmol/l 4. 4.0–4.9 mmol/l	8 5 3 1
DNA analysis
1. Causative mutation in LDLR, APOB or PCSK9	8
Clinical diagnosis
Definite Probable Possible Unlikely	>8 6­–8 3–5 <3

Source: Nordestgaard et al., 2018.[7] Published with permission from Oxford University Press.