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Synergistic effect of the D647G mutation in dnaE and endoMS disruption on the mutation rate. (A) The rate of spontaneous rifampicin resistance mutations was determined by fluctuation assay. Error bars show 95% confidence intervals (n = 20). (B) Rates of transition mutations determined by MA assay (Table 2). Overall transition mutation rates are shown. Average and standard errors for all lines are presented.
