Skip to main content
. 2018 Feb 3;27(7):1276–1289. doi: 10.1093/hmg/ddy043

Figure 3.

Figure 3.

Effect of heterozygous deletion of the ELP3 gene in the SOD1G93A mouse. (A) Mean disease onset was reduced by ELP3 heterozygous deletion: SOD1G93A/ELP3+/+ 105.8 ± 2.1 days, n = 45 versus SOD1G93A/ELP3+/− 98.7 ± 2.2 days, n = 40. Data are mean ± S.E.M., log-rank test, P = 0.0141. (B) Mean survival was not affected: SOD1G93A/ELP3+/+ 157.5 ± 1.6 days, n = 38 versus SOD1G93A/ELP3+/− 155.2 ± 1.5 days, n = 30. Data are mean ± S.E.M., log-rank test, P = 0.2307. (C) Relative quantification of the innervation of NMJs of the gastrocnemius muscle in symptomatic mice (post-natal day 104). Denervated NMJs were not affected: SOD1G93A/ELP3+/+ 43.7 ±3.5%, n = 6 versus SOD1G93A/ELP3+/− 40.7 ± 10.4%, n = 3. Data represent mean ± S.E.M., two-way ANOVA, P = 0.9173. (D) Quantification of ventral horn lumbar motor neurons, in function of the cell body area, in symptomatic mice (post-natal day 104). No differences were found between genotypes. Data represent mean ± S.E.M., two-way ANOVA, n = 3, P > 0.5.