Table 2.
BMD values for in vitro MN assay across varying BMR (units are µg/ml)
| AZA | CHL | HU | MEL | MMS | PRS | THI | Geometric mean | |
|---|---|---|---|---|---|---|---|---|
| BMR = 0.05 | ||||||||
| BMD | 0.0065 | 0.0099 | 0.2706 | 0.0052 | 0.0095 | 0.8737 | 0.0284 | |
| BMDL | 0.0047 | 0.0071 | 0.2015 | 0.0038 | 0.0073 | 0.6221 | 0.0199 | |
| BMDU | 0.0089 | 0.0140 | 0.3682 | 0.0073 | 0.0127 | 1.2562 | 0.0397 | |
| BMDU/BMDL | 1.88 | 1.99 | 1.83 | 1.94 | 1.74 | 2.02 | 1.99 | 1.91 |
| BMR = 0.5 | ||||||||
| BMD | 0.0522 | 0.0798 | 2.1713 | 0.0421 | 0.0764 | 7.0109 | 0.2276 | |
| BMDL | 0.0426 | 0.0626 | 1.7343 | 0.0337 | 0.0661 | 5.2717 | 0.1806 | |
| BMDU | 0.0635 | 0.1004 | 2.7736 | 0.0520 | 0.0877 | 9.7620 | 0.2821 | |
| BMDU/BMDL | 1.49 | 1.60 | 1.60 | 1.54 | 1.33 | 1.85 | 1.56 | 1.56 |
| BMR = 1 | ||||||||
| BMD | 0.0977 | 0.1493 | 4.0649 | 0.0788 | 0.1431 | 13.1250 | 0.4261 | |
| BMDL | 0.0819 | 0.1199 | 3.2729 | 0.0648 | 0.1275 | 9.9183 | 0.3489 | |
| BMDU | 0.1163 | 0.1846 | 5.1829 | 0.0953 | 0.1593 | 18.2930 | 0.5134 | |
| BMDU/BMDL | 1.42 | 1.54 | 1.58 | 1.47 | 1.25 | 1.84 | 1.47 | 1.50 |
| BMR = 2 | ||||||||
| BMD | 0.1830 | 0.2796 | 7.6116 | 0.1475 | 0.2679 | 24.5770 | 0.7978 | |
| BMDL | 0.1564 | 0.2284 | 6.1307 | 0.1237 | 0.2437 | 18.5530 | 0.6716 | |
| BMDU | 0.2142 | 0.3419 | 9.7468 | 0.1758 | 0.2937 | 34.4380 | 0.9389 | |
| BMDU/BMDL | 1.37 | 1.50 | 1.59 | 1.42 | 1.20 | 1.86 | 1.40 | 1.46 |
| BMR = 4 | ||||||||
| BMD | 0.3428 | 0.5238 | 14.2600 | 0.2764 | 0.5018 | 46.0430 | 1.4946 | |
| BMDL | 0.2961 | 0.4319 | 11.4010 | 0.2344 | 0.4595 | 34.5140 | 1.2847 | |
| BMDU | 0.3984 | 0.6383 | 18.4490 | 0.3271 | 0.5505 | 65.1430 | 1.7303 | |
| BMDU/BMDL | 1.35 | 1.48 | 1.62 | 1.40 | 1.20 | 1.89 | 1.35 | 1.45 |