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. 2018 Jul 31;4(8):e000205. doi: 10.1099/mgen.0.000205

Fig. 2.

Fig. 2.

Gene tree of penA, resistance patterns of cefixime and ceftriaxone, and penA polymorphisms. Heatmap: column 1, ST: the ST of the genomes harbouring the penA alleles. The two major STs (ST7363 and ST1901), single-locus variants of the former (ST7356, ST1932) and the latter (ST7360 and ST1579), and a new ST (double-locus variant of ST1901) are coloured. Columns 2–3: susceptible/resistant (S/R) categories according to the EUCAST MIC breakpoint of cefixime (CFM) and ceftriaxone (CRO). The presence or absence of genetic features is shown in columns 4–11 as marked: grey indicates absence, other colours indicate presence. Column 4: any mosaic penA allele. Columns 5–10: a specific mosaic penA allele. Column 11: penA V. The inset on the right is a schematic representation illustrating PBP2 amino acid sequences encoded by the penA alleles. The sequence blocks shaded with the same colour represent identical amino acid sequences. The susceptible penA allele reverted by recombination is composed of penA X (first half, white) and penA V (second half, yellow-green).