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PI3K links ASM contractile phenotype signaling with cell survival. A) Effect of PI3K inhibitors, LY294002 (LY, 20 μM) and wortmannin (W, 100 nM), on the protein abundance of Akt, sm-α-actin, and Bcl-2. LYD and WD are vehicle controls for LY294002 (0.2% DMSO) and wortmannin (0.01% DMSO), respectively. B) Effect of selective laminin-competing peptide YIGSR on the protein abundance of Akt. Results are representative of 3 independent experiments.
