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. 2013 Oct;27(10):3991–4003. doi: 10.1096/fj.12-221341

Figure 7.

Figure 7.

Lama2−/− mice do not develop allergen challenge-induced airway hyperreactivity. A) Comparison of airway reactivity between wild-type (WT) and Lama2−/− mice (n=4–7/group); results for Lama2−/− saline sensitization and saline challenge (s/s) and Lama2−/− OVA sensitization and OVA challenge (o/o) are superimposed. *P < 0.05 vs. WT (s/s)-treated mice; †P < 0.05 vs. WT (o/o). B) Comparison of caspase 3 activity between WT and Lama2−/− mice (n=3–4/group). *P < 0.05 vs. WT (s/s)-treated mice. C) Comparison of sm-α-actin-positive area relative to basement membrane (BM) between WT and Lama2−/− mice (n=3–4/group). *P < 0.05 vs. WT (s/s); †P < 0.05 vs. WT (o/o). D) H&E and immunohistochemistry staining for sm-α-actin and TUNEL staining in mouse whole-lung slices. Asterisks indicate TUNEL-positive apoptotic cells. Scale bars = 20 μm. E–G) Levels of OVA-specific IgE (E), IgG1 (F), and IgG2a (G) in mouse serum that was collected 24 h after the last OVA aerosol challenge. O.D., optical density. *P < 0.05 vs. WT (s/s)-treated mice.