Fig.3.

Bri3 co-localizes with AD amyloid plaques. Human brain sections stained with anti-Aβ/AβPP (6E10, green) and rabbit anti-Bri3 BRICHOS (red) antibodies from (A, B) sporadic AD case; (C, D) AD case with AβPPswe mutation; (E, F) AD case with AβPParc mutation; (G) healthy control; and (H) sporadic AD case stained using only the secondary antibody. The rectangles in A, C, and E indicate the areas shown in B, D, and F, respectively. All samples were counterstained with hematoxylin. Scale bars 50 μm. Images are representative of three independent experiments.