Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Sep 20;9:2150. doi: 10.3389/fimmu.2018.02150

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2018 Irons and Lau.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Cell non-autonomous ST6Gal-1 influences sialylation and abundance of early transitional B cell populations. CD45.1+ whole bone marrow cells from wild-type or St6gal1-KO mice were adoptively transferred to irradiated CD45.2+ hosts. Mice were allowed to recover for 6 weeks before analysis of bone marrow and splenic B cells. (A) SNA reactivity of bone marrow and splenic B cell subsets of CD45.1+ donor cells. (B) Frequencies of CD45.1+ IM, IgM-high, BMM, IgD-/CD21-, IgD+/CD21+, MZ, and FO B cells as a fraction of total CD45.1+ B cells (n = 5). (C) Immunofluorescence microscopy staining anti-IgM (red) and anti-IgD (green) in chimeras. Splenic B cell populations indicated are identified accordingly - T1: IgM+/IgD-, extrafollicular; T2 and FO: IgM-variable/IgD+, follicular, MZ: IgM+/IgD-, marginal sinus. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.