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. 2018 Sep 20;9:1294. doi: 10.3389/fphys.2018.01294

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Copyright © 2018 Madeddu, Gramignano, Astara, Demontis, Sanna, Atzeni and Macciò.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Relationship between nutritional status, leptina and cancer-related anemia. Impaired energy metabolism and low nutrients availability induced by cancer-associated chronic inflammation are involved in the impairment of erythropoiesis. Low iron as well as low heme synthesis as a consequence of altered efficiency of glucose metabolism impair erythropoiesis. Leptin, which decreases as a consequence of such metabolic/nutritional changes, can also influence erythropoiesis by itself. REE, resting energy expenditure.