Table 1.
Correlation between immunohistochemical staining and clinicopathological features in patients with muscle-invasive bladder cancer who underwent radical cystectomy
| Variables | All (n=58) | M-CSF
|
G-CSF
|
GM-CSF
|
||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Low n (%) | High n (%) | P-value | Low n (%) | High n (%) | P-value | Low n (%) | High n (%) | P-value | ||
| Median age, years (IQR) | 72 (65.3–76) | 0.77 | 0.58 | 0.06 | ||||||
| <70 | 20 (34) | 14 (70) | 6 (30) | 10 (50) | 10 (50) | 14 (70) | 6 (30) | |||
| ≥70 | 38 (66) | 24 (63) | 14 (37) | 15 (39) | 23 (61) | 16 (42) | 22 (58) | |||
| Sex, n (%) | 1.0 | 0.77 | 0.24 | |||||||
| Male | 43 (74) | 28 (65) | 15 (35) | 18 (42) | 25 (58) | 20 (47) | 23 (53) | |||
| Female | 15 (26) | 10 (33) | 5 (67) | 7 (47) | 8 (53) | 10 (67) | 5 (33) | |||
| T stage, n (%) | 1.0 | 0.20 | *0.02 | |||||||
| T2–3 | 46 (79) | 30 (65) | 16 (35) | 22 (48) | 24 (52) | 20 (43) | 26 (57) | |||
| T4 | 12 (21) | 8 (67) | 4 (33) | 3 (40) | 9 (80) | 10 (83) | 2 (17) | |||
| Variant, n (%) | 0.37 | 0.40 | 0.40 | |||||||
| Pure UC | 40 (69) | 28 (70) | 12 (30) | 19 (48) | 21 (52) | 19 (48)) | 21 (52) | |||
| UC with varianta | 18 (31) | 10 (56) | 8 (44) | 6 (33) | 12 (67) | 11 (61) | 7 (39) | |||
| LVI, n (%) | 0.54 | 0.08 | 0.77 | |||||||
| Negative | 16 (28) | 12 (67) | 4 (33) | 10 (63) | 6 (37) | 9 (56) | 7 (44) | |||
| Positive | 42 (72) | 26 (62) | 16 (38) | 15 (36) | 27 (64) | 21 (50) | 21 (50) | |||
| LN metastasis, n (%) | 1.0 | 0.32 | 0.51 | |||||||
| Negative | 47 (81) | 31 (66) | 16 (34) | 22 (47) | 25 (53) | 23 (49) | 24 (51) | |||
| Positive | 11 (19) | 7 (64) | 4 (36) | 3 (27) | 8 (73) | 7 (64) | 4 (36) | |||
Notes:
a
Squamous and glandular differentiation.
*
P<0.05.
Abbreviations: M-CSF, macrophage colony-stimulating factor; G-CSF, granulocyte-colony stimulating factor; GM-CSF, granulocyte macrophage colony-stimulating factor; UC, urothelial carcinoma; LVI, lymphovascular invasion; LN, lymph node; IQR, interquartile range.