Table 3.
Results of ambulatory blood pressure measurements in patients with rs1045642 ABCB1 polymorphisms undergoing amlodipine therapy
| CC (n=17)
|
CT (n=53)
|
TT (n=30)
|
||||
|---|---|---|---|---|---|---|
| Baseline | 12 weeks | Baseline | 12 weeks | Baseline | 12 weeks | |
| 24-hour SBP (mmHg) | 142.65±7.28 | 132.34±6.16 | 141.91±7.41 | 130.71±5.62 | 142.30±6.25 | 127.19±6.98 |
| Δ (mmHg) | −10.31±4.01 | −11.2±5.89 | −15.11±6.97 | |||
| Δ (%) | −7.23±2.32 | −7.89±3.48 | −10.61±4.34 | |||
| P, intragroup | 0.02 | 0.01 | 0.01 | |||
| P, intergroup (Kruskal–Wallis one-way ANOVA) | 0.04 | |||||
|
| ||||||
| 24-hour DBP (mmHg) | 87.52±7.52 | 81.05±6.38 | 89.51±7.94 | 82.91±5.76 | 87.83±6.92 | 79.46±6.06 |
| Δ (mmHg) | −6.47±2.21 | −6.60±2.88 | −8.37±4.12 | |||
| Δ (%) | −7.39±3.76 | −7.37±3.32 | −9.53±2.82 | |||
| P, intragroup | 0.03 | 0.02 | 0.02 | |||
| P, intergroup (Kruskal–Wallis one-way ANOVA) | 0.02 | |||||
|
| ||||||
| Daytime SBP (mmHg) | 145.71±4.71 | 138.31±4.4 | 144.63±4.81 | 134.43±4.24 | 144.69±5.21 | 130.15±5.50 |
| Δ (mmHg) | −7.40±3.43 | −10.20±4.82 | −14.54±8.09 | |||
| Δ (%) | −5.08±1.76 | −7.05±3.32 | −10.05±3.82 | |||
| P, intragroup | 0.01 | 0.02 | 0.01 | |||
| P, intergroup (Kruskal–Wallis one-way ANOVA) | 0.03 | |||||
|
| ||||||
| Daytime DBP (mmHg) | 90.13±5.61 | 82.81±5.24 | 88.35±5.83 | 82.26±6.23 | 88.61±8.13 | 79.76±4.02 |
| Δ (mmHg) | −7.32±4.62 | −6.09±3.72 | −8.85±6.32 | |||
| Δ (%) | −8.12±2.19 | −6.89±4.28 | −9.99±6.11 | |||
| P, intragroup | 0.03 | 0.04 | 0.02 | |||
| P, intergroup (Kruskal–Wallis one-way ANOVA) | 0.04 | |||||
|
| ||||||
| Nighttime SBP (mmHg) | 130.21±6.71 | 124.81±5.11 | 129.51±5.83 | 120.82±5.21 | 128.46±5.95 | 117.92±8.81 |
| Δ (mmHg) | −5.40±3.93 | −8.69±4.09 | −10.54±5.57 | |||
| Δ (%) | −4.15±3.11 | −6.71±2.49 | −8.21±4.15 | |||
| P, intragroup | 0.02 | 0.01 | 0.02 | |||
| P, intergroup (Kruskal–Wallis one-way ANOVA) | 0.04 | |||||
|
| ||||||
| Nighttime DBP (mmHg) | 85.44±4.82 | 78.10±4.67 | 86.24±4.87 | 77.35±4.27 | 84.69±8.18 | 73.39±7.91 |
| Δ (DBP) | −7.34±5.71 | −8.89±3.43 | −11.3±5.53 | |||
| Δ (%) | −8.59±3.41 | −10.31±4.22 | −13.34±5.31 | |||
| P, intragroup | 0.01 | 0.01 | 0.02 | |||
| P, intergroup (Kruskal–Wallis one-way ANOVA) | 0.03 | |||||
|
| ||||||
| Daytime HR (beats/min) | 71.22±6.12 | 68.42±5.98 | 69.81±5.86 | 70.01±4.76 | 68.28±6.14 | 66.86±5.17 |
| Δ (beats/min) | −2.80±0.92 | 0.20±0.70 | −1.42±0.09 | |||
| Δ (%) | −3.9±0.3 | 0.28±0.3 | −2.80±0.42 | |||
| P, intragroup | 0.1 | 0.5 | 0.3 | |||
| P, intergroup (Kruskal–Wallis one-way ANOVA) | 0.25 | |||||
Note: Data are reported as mean ± SD.
Abbreviation: HR, heart rate.