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. Author manuscript; available in PMC: 2018 Sep 27.
Published in final edited form as: Glob Vaccines Immunol. 2016 May 27;1(2):44–52. doi: 10.15761/GVI.1000112

Figure 3. Mtb antigens activate B cells.

Figure 3

A. Flow cytometric plot depicting the level of CD69 expressed by CD19+ B cells in PBMC cultures. Shown are plots from an LTBI subject. WCL also induced CD69 expression by non-B cells as reported in Hochberg et al., 2016 [3]. B. Composite data demonstrating an increase in CD69+ B cells following treatment with the stimuli indicated on figure. WCL from Mtb increased B cell expression of CD69, whereas anti-CD40 or a combination of E. coli LPS (TLR4 ligand) and PAM3CSK4 (TLR2 ligand) did not. C. Composite data demonstrating an increase in TLR2+ B cells following treatment with the stimuli indicated on figure. WCL from Mtb increased B cell expression of TLR2 in both groups. D. In contrast, TLR4 is not upregulated significantly by any of the stimuli tested in either group. Horizontal bars indicate medians.