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. Author manuscript; available in PMC: 2019 Sep 1.
Published in final edited form as: Diabetes Obes Metab. 2018 Sep;20(Suppl 2):51–63. doi: 10.1111/dom.13402

Figure 13.

Figure 13.

Folding away from the hormone core of insulin residues B24-B30 upon engagement with μIR. The receptor-bound insulin B chain is in black and A chain in white, overlaid with the B chain of the free hormone in cyan. The schematic is based on PDB entries 4INS [6] and 4OGA [41].