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. Author manuscript; available in PMC: 2019 Sep 20.
Published in final edited form as: Cell. 2018 Sep 13;175(1):133–145.e15. doi: 10.1016/j.cell.2018.08.020

Figure 2: Casp2 is required for NASH development.

Figure 2:

A) IHC of formalin-fixed paraffin-embedded (FFPE) liver sections from indicated mouse strains. H&E reveals tissue composition, macrovesicular fat and hepatocyte ballooning. Oil Red O (ORO) visualizes lipid droplets. p62 and F4/80 immunostaining show Mallory-Denk Bodies (MDB) and macrophage infiltration, respectively. Scale bar: 100 μm. Staining intensity per high magnification field (HMF) was determined by ImageJ of 8 fields per section (WT/MUP: n = 8; Casp2−/−/MUP: n = 6). Bar graphs: mean ± SEM. B) Serum and liver triglycerides (TG) and cholesterol (Chol) in indicated mouse strains (WT/MUP: n = 10; Casp2−/−/MUP: n = 7). Mean ± SEM. *p < 0.05, **p < 0.005, ***p < 0.001.