Skip to main content
. 2018 Sep 17;128(10):4711–4726. doi: 10.1172/JCI96259

Figure 9. Exogenous therapeutic inhibition of Neo1 attenuates inflammation and fosters resolution programs.

Figure 9

The therapeutic potential of Neo1 blockade was evaluated by application of anti-Neo1 Ab 4 hours after ZyA peritonitis induction at the peak of inflammation, and peritoneal lavages were collected at 12, 24, and 48 hours. (A) Total leukocyte cell numbers were enumerated and PMNs, classical and nonclassical monocytes, peritoneal MΦ, and monocyte-derived MΦ efferocytosis were measured by FACS. (B) Resolution index. (C) IL-10 and TGF-β levels 12 hours after ZyA injection. (D) PCNA immunohistochemistry images (n = 4/condition, magnification ×630, scale bar 200 μm) and the calculated PCNA index. Results represent at least 2 independent experiments and are expressed as mean ± SEM (A) and median ± 95% CI (D) (n = 8–12 per group). Statistical analysis was done by unpaired Student’s t test, *P < 0.05, **P < 0.01, ***P < 0.001.