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. 2018 Aug 27;128(10):4387–4396. doi: 10.1172/JCI99005

Figure 5. Hu-mice receiving αCD40.HIV5pep plus poly(I:C) therapeutic vaccination show improved control of HIV-1 replication after cART discontinuation.

Figure 5

(A) Schematic diagram of the experimental design. Hu-mice infected with HIV-1 were treated with cART from 4 wpi to 11 wpi. The mice were vaccinated with αCD40.HIV5pep plus poly(I:C) or treated with poly(I:C) or PBS as control at 7.5 wpi and 10 wpi. Virus rebound was detected by PCR weekly after cART cessation at 11 wpi. (B) Plasma HIV-1 RNA in each group at indicated time points. (C) Kinetic analysis of HIV-1 rebound after cART cessation. (D) Plasma HIV-1 RNA at 12, 13, 14, 15 wpi from each mouse in different treatment groups. (B–D) Combined data from 2 independent experiments with mean values ± SEM (HIV+cART+PBS, n = 6; HIV+cART+poly(I:C), n = 7; HIV+cART+poly(I:C)+αCD40.HIV5pep, n = 8). *P < 0.05, **P < 0.01, ***P < 0.001. Gehan-Breslow-Wilcoxon test (C) or 1-way ANOVA and Bonferroni’s post hoc test (D) was performed.