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. 2018 Aug 7;128(10):4573–4587. doi: 10.1172/JCI121957

Figure 2. Similar frequency of HBsAg-specific B cells in diverse cohorts of HBV-infected patients.

Figure 2

(A) Frequency of HBsAg-specific B cells in 5 healthy HBV-unvaccinated (HC unvac), 18 healthy HBV-vaccinated (HC vac), 11 acute HBV, 21 resolved HBV, and 96 CHB patients out of total CD19+ B cells. (B) Frequency of HBsAg-specific B cells out of total CD19+ B cells in different phases of CHB: 22 HBeAg+ chronic infection (eAg+CInf), 24 HBeAg+ chronic hepatitis (eAg+CHep), 24 HBeAg– chronic hepatitis (eAg–CHep), and 26 HBeAg– chronic infection (eAg–CInf). (C) No correlation between frequency of HBsAg-specific B cells and serum levels of HBsAg, HBV DNA, and ALT. (D) Frequency of HBsAg-specific B cells among 51 CHB patients infected with 5 different HBV genotypes. Data are presented as median, and statistical analysis was performed by the Kruskal-Wallis test followed by Dunn’s multiple comparisons test. *P < 0.05 (A, B, and D); Spearman’s rank correlation (C).