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. 2018 Aug 7;128(10):4573–4587. doi: 10.1172/JCI121957

Figure 3. Longitudinal profile of B cell responses in acute HBV patients.

Figure 3

(A) Frequency of global plasmablasts (CD19+CD10–CD21–CD27++CD38++) out of total B cells (CD19+) were analyzed at the indicated different time points in 6 patients with acute HBV (left) and in 5 patients with acute dengue infection (right). Time points are indicated as days after onset of clinical symptoms. Virological features of acute HBV and dengue are indicated at the top of the figures. (B) Longitudinal frequency of HBsAg-specific B cells in the 6 acute hepatitis B patients compared with the frequency obtained in 21 subjects with resolved HBV infection (anti-HBc+, anti-HBs+; open circles). HBsAg-specific B cells were calculated as the frequency of memory double-positive HBsAg-D550+D650+ B cells out of total CD19+ B cells. Each symbol represents a single patient.