Skip to main content
. 2018 Jul 26;128(10):4329–4342. doi: 10.1172/JCI99315

Figure 6. CD36 deletion in ECs or CMs reduces heart lipid storage during fasting.

Figure 6

(A) Heart tissue sections from Cd36fl/fl, EC-Cd36–/–, and CM-Cd36–/– mice were stained with BODIPY 493/503. Scale bars: 50 μm. (B) Electron micrographs (original magnification ×3,400, top row, and ×15,000, bottom row) of myocardial tissue showing a significant decrease in lipid droplets within the sarcoplasm of CMs from EC-Cd36–/– and CM-Cd36–/– mice. Yellow arrows indicate lipid droplets. (C) Lipid droplet numbers in heart tissue sections (n = 4) from Cd36fl/fl, EC-Cd36–/–, and CM-Cd36–/– mice (expressed per 100 μm2). (D) Heart TG content in Cd36fl/fl (n = 10), EC-Cd36–/– (n = 6), and CM-Cd36–/– mice (n = 3). Data represent the mean ± SD. *P < 0.05, #P < 0.01, and §P < 0.001 compared with Cd36fl/fl controls; 1-way ANOVA with Dunnett’s multiple comparisons test.