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. 2018 Sep 4;128(10):4441–4453. doi: 10.1172/JCI121924

Figure 7. Immune transcripts associated with dMMR mutation signature activity in mCRPC tumors from the SU2C/PCF dataset (n = 168).

Figure 7

(A) Expression of immune checkpoint–related genes associated with dMMR mutation signature activity (32 immune checkpoint genes analyzed; Overall). (B) Expression of immune checkpoint–related genes associated with dMMR mutation signature cancers (32 immune checkpoint genes analyzed; Bone Metastases). (C) Expression of immune checkpoint–related genes associated with dMMR mutation signature activity (32 immune checkpoint genes analyzed; Lymph Node Metastases). (D) Discovery of immune mRNA transcripts associated with, in RNA-Seq analyses, dMMR mutation signature activity (762 immune transcript NanoString panel; Overall). (E) Discovery of immune mRNA transcripts associated with, in RNA-Seq analyses, dMMR mutation signature activity (762 immune transcript NanoString panel; Bone Metastases). (F) Discovery of immune mRNA transcripts associated with, in RNA-Seq analyses, dMMR mutation signature activity (762 immune transcript NanoString panel; Lymph Node Metastases).