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. 2018 Sep 4;128(10):4454–4471. doi: 10.1172/JCI96138

Figure 5. REVERBa selectively regulates GC action depending on time of day.

Figure 5

(A) Daytime-regulated GC targets were further stratified for regions of GR-REVERBa co-binding from Figure 3. (B) Gene ontology (Enrichr) of GC-regulated, co-bound, REVERBa-dependent genes in the day. (C) Nighttime-regulated GC targets were further stratified for regions of GR-REVERBa co-binding from Figure 3. (D) Gene ontology (Enrichr) of GC-regulated, co-bound, REVERBa-dependent genes at night. (E) Dex suppression test via measurement of serum corticosterone at both ZT6 and ZT18 in WT and REVERBaKO mice with a single dose of dex 1 mg/kg. C57BL/6 (WT) and REVERBaKO mice were given 1 mg/kg i.p. dex or vehicle at ZT6 every 48 hours for 8 weeks. (F) C57BL/6 (WT) and REVERBaKO mice were given 1 mg/kg i.p. dex or vehicle at ZT6 every 48 hours for 8 weeks. Thymus weight was measured. Corticosterone measurement, n = 5–12; thymus weight, n = 7–8, *P < 0.05, **P < 0.01, Mann-Whitney U test; shown as median.