Table 2. miRs regulated by cytokines and Givinostat.

			Log2FC		Adjusted p-value
Group	MicroRNA	Human ortholog	24 h_Cyt vs Ctrl	24 h_Giv_Cyt vs Cyt	24 h_Cyt vs Ctrl	24 h_Giv_Cyt vs Cyt
A: Cyt↓, Giv↑, 24 h	rno-miR-7a-2-3p	hsa-miR-7-2-3p	-0.22	0.36	8.90E-03	6.71E-06
	rno-miR-466b-2-3p	hsa-miR-466	-0.26	0.30	4.96E-02	3.29E-02
	rno-miR-652-5p	hsa-miR-652-5p	-0.56	0.32	1.20E-27	2.66E-09
B: Cyt↑, Giv↓, 24 h	rno-miR-29c-3p	hsa-miR-29c-3p	0.71	-0.20	5.75E-35	2.61E-03
	rno-miR-96-5p	hsa-miR-96-5p	0.70	-0.24	3.19E-36	6.24E-05
	rno-miR-101a-3p	hsa-miR-101-3p	0.60	-0.30	2.90E-33	7.85E-09
	rno-miR-140-5p	hsa-miR-140-5p	0.17	-0.13	5.05E-05	8.10E-03
	rno-miR-340-5p	hsa-miR-340-5p	0.39	-0.22	1.91E-24	5.44E-08
	rno-miR-384-5p	hsa-miR-384	0.38	-0.30	1.44E-09	2.48E-05
	rno-miR-455-5p	hsa-miR-455-5p	0.19	-0.15	6.91E-08	6.24E-05
	rno-miR-3584-5p	No human ortholog	0.38	-0.14	1.46E-32	2.68E-05
C: Cyt↑, Giv↑, 24 h	rno-miR-146a-5p	hsa-miR-146a-5p	0.59	0.16	5.17E-32	5.17E-32
Group	MicroRNA	Human ortholog	6 h_Cyt vs Ctrl	6 h_Giv_Cyt vs Cyt	6 h_Cyt vs Ctrl	6 h_Giv_Cyt vs Cyt
D: Cyt↑, Giv↓, 6 h	rno-miR-146b-5p	hsa-miR-146b-5p	0.44	-0.42	5.70E-07	3.02E-06

miRs fulfilling the requirements to be regulated both by cytokines and by Givinostat in the presence of cytokines, sorted into groups.