Figure 2.

Serum beta-hCG and ALT levels during chemotherapy. Both patients responded extremely well to the 5-day actinomycin D regimen (the timing of actinomycin D treatment was shown with black arrow). Beta-hCG dropped to less than 2 mIU/mL after 2 and 3 cycles, respectively (each dot on the red line refers to each hCG value tested during surveillance). Notably, both ALT levels would elevate significantly 3 to 7 days after each cycle's actinomycin injection (each dot on the blue line refers to each ALT value tested during surveillance). Neither organic lesion could be found in ultrasonography nor hepatitis virus infection could be suspected in the serum test. We successfully ameliorated the liver condition before each new cycle by using polyene phosphatidyl choline, magnesium isoglycyrrhizinate, and ademetionine 1,4-butanedisulfonate.