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Schematic explanation of the hypothalamic-mesolimbic brain circuit state in the following: A) healthy brain; B) obese Zucker brain; and C) obese Zucker brain with NAcc-DBS, showing the disruptive mechanism of action theory [9,10]. Partially adapted from [20,28] [Arc: arcuate, LH: lateral hypothalamus, VTA: ventral tegmental area, NAcc: nucleus accumbens].
