Table 1. Descriptive statistics of included COAST participants.
| Characteristic | Neither (A-A-) (N = 12) |
Atopic* only (A-A+) (N = 15) |
Asthma only (A+A-) (N = 34) |
Atopy* & Asthma (A+A+) (N = 28) |
p value | |
|---|---|---|---|---|---|---|
| Age, years (SD) | 15.1 (0.3) | 15.1 (0.4) | 15.3 (0.7) | 15.4 (0.6) | 0.26 | |
| Body-mass index, kg/m2 (SD) | 20.3 (3.2) | 22.2 (4.2) | 23.7 (5.9) | 24.6 (4.4) | 0.06 | |
| Male gender, % (N) | 50% (6) | 60% (9) | 53% (18) | 68% (19) | 0.61 | |
| Race, % (N) | Caucasian | 92% (11) | 100% (15) | 91% (31) | 86% (24) | 0.26 |
| African-American | 0% | 0% | 6% (2) | 14% (4) | 0.21 | |
| Asian | 8% (1) | 0% | 3% (1) | 0% | 0.38 | |
| Systolic Blood Pressure, mmHg (SD) | 114 (9) | 111 (9) | 113 (12) | 114 (8) | 0.70 | |
| Diastolic Blood Pressure, mmHg (SD) | 64 (5) | 63 (4) | 65 (5) | 64 (4) | 0.68 | |
| Asthma status at Exam 13 | None | 100% (12) | 100% (15) | 26% (9) | 14% (4) | N/A |
| Intermittent | 0% | 0% | 18% (6) | 39% (11) | ||
| Mild-persistent | 0% | 0% | 47% (16) | 29% (8) | ||
| Moderate-persistent | 0% | 0% | 6% (2) | 18% (5) | ||
| Severe | 0% | 0% | 3% (1) | 0% | ||
| Medication Use at year 15 |
Oral corticosteroid | 0% | 0% | 6% (2) | 11% (3) | 0.57 |
| Inhaled corticosteroid | 0% | 0% | 50% (17) | 61% (17) | <0.0001 | |
| Leukotriene antagonist | 0% | 7% (1) | 24% (8) | 14% (4) | 0.21 | |
| Albuterol | 17% (2) | 0% | 74% (25) | 86% (24) | <0.0001 | |
| Long acting beta agonist | 0% | 0% | 32% (11) | 21% (6) | 0.01 | |
| Total IgE, median [25th, 75th] | 45 [17,88] |
59 [20,132] |
83 [53,474] |
136 [51,320] |
0.08 | |
| Blood eosinophil, median [25th, 75th] | 82 [61,128] |
198 [112,309] |
216 [92,450] |
176 [101,280] |
0.27 | |
| Fractional exhaled nitric oxide, median [25th, 75th] | 13 [12,19] |
13 [9,18] |
20 [10,38] |
18 [11,34] |
0.33 | |
| Right Carotid Artery Bifurcation μm (SD) | 589 (73) | 653 (86) | 649 (78) | 677 (107) | 0.04 | |
| Right Common Carotid IMT μm (SD) | 558 (42) | 590 (76) | 597 (65) | 602 (74) | 0.26 | |
Continuous measures are summarized as either mean (standard deviation, SD) or median [25th, 75th], and compared across groups using an analysis of variance. Total IgE, blood eosinophil counts, and exhaled nitric oxide were log-transformed for analysis. Categorical measures are summarized as rates (%) and compared across groups using Fisher’s exact test. Participants may select more than one race category so totals may sum to >100%.
*Physician Diagnosed Atopic Disease (atopic dermatitis and/or allergic rhinitis)