Table 4. Univariate and multivariate Cox regression analysis predicting recurrence-free survival rates after primary TURBT.

	Univariate		Multivariate
	HRa (95%CIb)	P-value	HR (95%CI)	P-value
Gender:
Male	1.0 (Reference)
Female	0.87 (0.45–1.68)	0.681	-c	-
Age (year):
< 68	1.0 (Reference)
≥ 68	0.77 (0.46–1.30)	0.329	-	-
Smoking
Yes	1.0 (Reference)		1.0
No	2.0 (0.90–4.45)	0.091	2.74 (1.16–6.48)	0.021
T Stage:
Ta	1.0 (Reference)
T1	0.91 (0.53–1.57)	0.739	-	-
Grade:
Low	1.0 (Reference)		1.0 (Reference)
High	0.62 (0.34–1.13)	0.119	0.86 (0.26–2.83)	0.807
Risk stratification:
Low	1.0 (Reference)		-	-
Intermediate	1.03 (0.56–1.90)	0.922	-	-
High	0.59 (0.29–1.20)	0.148	-	-
Adjuvant intravesical therapy:
No	1.0 (Reference)		1.0 (Reference)
Yes	0.44 (0.25–0.75)	0.003	0.97 (0.27–0.35)	0.000
Percentage of Foxp3+ T cells:
< 17.98	1.0 (Reference)		1.0 (Reference)
≥ 17.98	2.03 (1.21–3.43)	0.008	4.45 (1.71–11.5)	0.002

^a hazard ratio

^b 95% confidence interval

^c not calculated