Fig 3. The phosphoprotein biological interaction network in T. cruzi-infected cells.

Cellular pathways associated with the altered phosphoproteins as a result of T. cruzi infection were derived and grouped at the meta-level using enrichment analysis of significant protein changes mapped to the following canonical pathway groups: immunological response, fibrotic extracellular response, neuronal response, intracellular signaling, and stress-associated signaling. Proteins were categorized into type or class (node color) and degree of connection to their respective cellular signaling pathways (node size).