Table 1. SEC-MALS analysis of CHIP proteins.
The true molecular weight (mw) in Daltons is provided along with the fractional contribution of each oligomeric species (Xmer) of CHIP identified. With some proteins, a small amount was detected as very high molecular weight (VWMW).
| Protein | 2mer | 4mer | 6mer | 10mer | 20mer | 50mer | VHMW |
|---|---|---|---|---|---|---|---|
| WT (mw) | 7.62E+04 | 1.43E+05 | 2.32E+05 | 4.87E+06 | |||
| WT (%) | 69.7% | 25.2% | 4.8% | 0.4% | |||
| K30A (mw) | 7.31E+04 | 1.38E+05 | 2.51E+05 | 1.86E+07 | |||
| K30A (%) | 80.4% | 16.4% | 2.6% | 0.7% | |||
| T246M (mw) | 4.13E+05 | 8.01E+05 | 1.99E+06 | ||||
| T246M (%) | 91.0% | 7.4% | 1.6% | ||||
| H260Q (mw) | 8.13E+04 | 3.97E+05 | 8.29E+05 | ||||
| H260Q (%) | 28.5% | 67.8% | 3.5% |