Table 2. Elevated plus maze, marble burying, olfactory sensing, and open field testing in mice.

The performance measurements from the elevated plus maze test, the marble-burying assay, and buried food test for olfactory function are represented by the mean ± SEM from mice with the indicated genotypes, † p < 0.05 comparing M/M to T/T and T/M; ‡ p < 0.05 and ¶ p = 0.07 comparing −/− and +/+.

	T246/T246	T246/M246	M246/M246	CHIP+/+	CHIP−/−
Elevated plus maze
Percent open arm time	32 ± 3	30 ± 4	36 ± 4	6 ± 3	30 ± 10 ‡
Percent open arm entries	39 ± 2	41 ± 2	42 ± 3	81 ± 4	60 ± 11
Total number of entries	28 ± 2	27 ± 2	28 ± 3	21 ± 4	27 ± 6
Number of marbles buried
First test (age 12 w)	16 ± 0.6	18 ± 0.4	11 ± 1.7 †
Second test (age 32 w)	17 ± 0.4	16 ± 0.7	13 ± 1.3 †
Olfactory test
Latency to find food (s)	267 ± 74	189 ± 52	289 ± 95
Percent of group finding food	80%	95%	89%
Open field test
# of crossings, Test 1				124 ± 43	289 ± 72 ¶
# of crossings, Test 2				313 ± 39	433 ± 94