. 2018 Sep 21;11:6119–6128. doi: 10.2147/OTT.S172717

Table 1.

Basic information regarding the studies

Study	Year	Tumor type	N	M/F ratio	Region	Participants		Line of apatinib	Outcome index
Study	Year	Tumor type	N	M/F ratio	Region	Control	Treatment	Line of apatinib	Outcome index
Li et al¹¹	2013	Gastric cancer	144	109:33	China	Placebo	Apatinib (850 mg qd or 425 mg bid)	Third line	ORR, DCR, PFS and OS, adverse reaction
Li et al¹⁶	2017	Hepatocellular carcinoma	40	–	China	TACE	Oral apatinib (unknown dose)	Unknown	CR, PR, SD, PD, survival rate of half year/1 year, total survival rate, VEGF and MMP-9 level, adverse reaction
Lu et al¹⁵	2017	Hepatocellular carcinoma	44	33:9	China	TACE	Oral apatinib (500 mg qd) + TACE	Unknown	AFP level, ORR, PFS, adverse reaction
Guo and Jing¹⁴	2017	Nonsquamous non-small-cell lung cancer	39	20:19	China	Received chemotherapy	Oral apatinib (500 mg qd) + docetaxel	Second line	PFS, DCR, ORR, adverse reaction
Wang et al¹³	2017	Nonsquamous non-small-cell lung cancer	128	87:41	China	Received chemotherapy	Apatinib + chemotherapy (unknown dose)	Second line	PFS, OS, CR, PR, SD, PD, adverse reaction
Zhang et al¹²	2012	Nonsquamous non-small-cell lung cancer	135	–	China	Placebo	Apatinib (750 mg qd)	Third line	CR, PR, SD, PD, PFS, adverse reaction
Li et al¹⁷	2016	Gastric cancer	273	201:66	China	Placebo	Apatinib (850 mg qd)	Third line	CR, PR, SD, PD, OS, PFS, adverse reaction

Abbreviations: ORR, objective response rate; DCR, disease control rate; PFS, progression-free survival; OS, overall survival; CR, complete remission; PR, partial remission; SD, stable disease; PD, progression disease; AFP, alpha fetoprotein.