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Adverse reactions of the apatinib group vs the control group
| Adverse reaction | Study no | RR | Min 95% CI | Max 95% CI | P-value |
|---|---|---|---|---|---|
| Myelosuppression | 5 | 1.45 | 0.52 | 4.06 | 0.48 |
| Nausea and vomiting | 3 | 1.00 | 0.63 | 1.58 | 0.99 |
| Hypertension | 5 | 8.38 | 4.89 | 14.37 | <0.005 |
| Proteinuria | 5 | 2.66 | 1.72 | 4.11 | <0.005 |
| Hand-foot syndrome | 5 | 11.50 | 5.68 | 23.68 | <0.005 |
| Diarrhea | 4 | 2.63 | 1.20 | 5.79 | 0.016 |
