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. 2018 Sep 21;11:1971–1982. doi: 10.2147/JPR.S164186

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© 2018 Lin and Yu. This work is published and licensed by Dove Medical Press Limited

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Evaluation of animal model.

Notes: (A) H&E staining (200×) shows that the colon specimens of control (left) and WAS (right) groups are intact, without congestion and obvious inflammatory cell infiltration. (B) The AWR score of WAS rats is significantly higher than that of the control group. (C) The withdrawal events of the WAS group in VFF test are enhanced compared to the control rats. (D) VMR cure (left) and summary data (right) for raw VMR responses to CRD at different pressures in control and WAS rats. VMR amplitude of the WAS group is higher than that of the control rats. Bars: (A) = 100 µm; n of each group = 6; *P<0.05, compared to control.

Abbreviations: AWR, abdominal withdrawal reflex; CRD, colorectal distension; VFF, Von Frey filament; VMR, visceromotor response; WAS, water avoidance stress.