Table 1. Diagnostic value of candidate biomarkers of liver fibrosis.

	Value	Sens	Spec	Predictive value	AUC	Publication, yearRef	Etiology	Definition of fibrosis
Gas6	30 ng/mL	84%	56%	N/A	0.734	Bellan et al. 201646	Mixed, 92% viral	Ishak ≤1
	42 ng/mL	64%	95%	N/A	0.788	Bellan et al. 201646		Ishak ≥4
M2BP	2.21 C.O.I.	88.2%	78.7%	PPV 58.9%, NPV 94.5%	0.812	Toshima et al. 201550	HCV	Metavir ≥3
	1.00 C.O.I.	67%	70%	PPV 53%, NPV 81%	0.680	Nakamura et al. 201752	HBV	Ishak ≥3
	2.00 C.O.I.	69%	74%	PPV 57%, NPV 83%	0.795	Nakamura et al. 201752	HCV	Ishak ≥3
	1.57 C.O.I.	85.9%	74.6%	N/A	0.879	Abe et al. 201553	NAFLD	Metavir ≥3
	1.40 C.O.I.	83%	90%	PPV 69%, NPV 95%	0.933	Umemura et al. 201554	PBC	Metavir ≥3
	3.70 C.O.I.	64.3%	83.3%	N/A	0.747	Nishikawa et al. 201655	Autoimmune hepatitis	Metavir ≥3
OPN	2.9 ng/mL	96.4%	94.1%	N/A	0.957	Huang et al. 201077	HCV	Metavir ≥3
	124 ng/mL	97.1%	100%	N/A	0.997	Matsue et al. 201579	HCV	Metavir ≥3
PlGF	20.2 pg/mL	79%	63%	N/A	0.758	Krawczyk et al. 201784	Mixed	Desmet Scheuer ≥2
	21.9 pg/mL	N/A	N/A	N/A	0.771	Krawczyk et al. 201784	Mixed	Desmet Scheuer ≥3
GDF15	1582.8 pg/mL	94%	67%	N/A	0.854	Krawczyk et al. 201784	Mixed	Desmet Scheuer ≥2
	1563.7 pg/mL	N/A	N/A	N/A	0.901	Krawczyk et al. 201784	Mixed	Desmet Scheuer ≥3
HGF	2598 pg/mL	97%	64%	N/A	0.849	Krawczyk et al. 201784	Mixed	Desmet Scheuer ≥2
	2085.7 pg/mL	N/A	N/A	N/A	0.888	Krawczyk et al. 201784	Mixed	Desmet Scheuer ≥3

Abbreviations: AUC, area under the curve; C.O.I., cut-off index; M2BP, Mac-2 binding protein; GDF15, growth differentiation factor 15; HGF, hepatocyte growth factor; N/A, not available; NPV, negative predictive value; OPN, osteopontin; PlGF, placental growth factor; PPV, positive predictive value; Sens, sensitivity; Spec, specificity.